As Nejire's Internship mentor, the two seem to have a close friendship, as Ryuko was willing to listen to Nejire's offer to recruit Ochaco and Tsuyu into her office, and did not object to Nejire throwing her arms around her.
Thanks to Nejire's recommendation, Ochaco Uraraka and Tsuyu Asui are hired by Ryukyu for internship. Both respects the Pro Hero and are grateful that she accepts them as intern. On the other hand, Ryuko thinks that both have potential, and that the internship will help to develop their fighting skills. Ryuko relies enough on Ochaco and Tsuyu's abilities to consider them fit to participate in the raid against the Shie Hassaikai.